脊椎动物NF-κB1/2基因亚家族分子进化和功能分歧分析

doi:10.11843/j.issn.0366-6964.2015.11.010

Abstract

Abstract:

The objective of this study was to analyze the reasons of different functions of NF-κB1/2 and to identify the evolutionary status of its domains.The sequence information of NF-κB1/2 was analyzed by following bioinformatic methods，including multiple sequence alignment phylogenetic tree construction and selective pressure prediction.The results showed that there was no intersection among vertebrate NF-κB1/2 during evolution，and RHD and IPT were highly conserved；ANK had diverged among both orthologous and paralogous structures；DD showed a high conservation with orthologous structures but a large difference with paralogous structures.Our results suggested that NF-κB1/2 were highly conservative among vertebrates，and the sequence variation of ANK might be an important factor causing the different functions of NF-κB1/2 in vertebrate，and DD might be one of the reasons for the divergence of NF-κB1/2 genes.

CLC Number:

Q953

GAN Xiang，WANG Ji-wen，LIU He-he，LI Liang，SUN Wen-qiang，WANG Yu-shi，ZHANG Tao，CHEN Da，HUANG Hui-lan. Molecular Evolution and Functional Differences Analysis of NF-κB1/2 Gene Subfamily of Vertebrate[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(11): 1987-1993.

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Molecular Evolution and Functional Differences Analysis of NF-κB1/2 Gene Subfamily of Vertebrate

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